PharmGKB

PharmGKB is a freely accessible NIH-funded resource that provides information about pharmacogenomics, that is, how human genetic variation affects response to medications. PharmGKB collects, curates and disseminates knowledge about clinically actionable gene-drug associations and genotype-phenotype relationships. It includes:

• Drug label annotations with pharmacogenomics (PGx) information;
• Clinical guideline annotations to be used by prescribers;
• Curated pathways, which are evidence-based diagrams showing how drugs are metabolized;
• Drug annotations summarizing published evidence for the relationship between a particular genetic variant and a medication;
• Very Important Pharmacogene (VIP) overviews of genes that are particularly important in the field of pharmacogenomics;
• Variant annotations, which are summaries of an association between a single genetic variant and a drug response.

PharmGKB is funded by the National Human Genome Research Institute (NHGRI) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which are part of the United States National Institutes of Health (NIH). It is managed at Stanford University.